the Research Program PRETORIAN
Τhe PRETORIAN project is dedicated to harnessing experimental discoveries concerning two novel chemical structures displaying remarkable anti-cancer properties. These discoveries are being advanced as pioneering therapeutic agents for cancer treatment.
The selection of the PRETORIAN compounds followed a rigorous evaluation process, involving the assessment of the biological activities of hundreds chemical compounds by the research teams led by Professors Aristides Eliopoulos (School of Medicine, National and Kapodistrian University of Athens) and George Vasilikogiannakis (Department of Chemistry, University of Crete). he most potent compound served as blueprint for the synthesis of derivatives, with the goal of amplifying their biological efficacy. This resulted in the development of two distinct chemical structures derived from the original compound.
The PRETORIAN project is funded by the General Secretariat for Research and Technology of Greece for the preclinical evaluation of these innovative compounds, with the following specific objectives:
specific objectives
Anticancer activity in cancer cell lines
Comprehensive in vitro and in vivo evaluation as monotherapies or in combination with other chemotherapeutic or biological agents.
Mechanistic studies
Determining the impact of the compounds on biological networks.
Molecular targets
Assessing the conversion of pro-drug molecules into active final compounds.
In vivo preclinical models
Conducting toxicological analyses in experimental animals (mice).
Toxicity studies
Securing intellectual property rights (patents) and developing commercialization strategies for the results.
News and Latest Research Findings
Our Patent application in NKUA News Hub
Reference to Professor Eliopoulos and the PRETORIAN team in the National and Kapodistrian University of Athens Hub for filing a patent application with the European Patent Office (EPO).
“HOT” Publication
Η εργασία των Kalaitzakis, Bosveli, Montagnon και Vassilikogiannakis με τίτλο "Sequential visible light-induced reactions using different photocatalysts: Transformation of furans into 2-pyridones via γ-lactams using a new ring expansion reaction", δημοσιεύεται στο περιοδικό Chemistry–A European Journal ως «hot paper».
Ομιλία του καθ. κ. Αριστείδη Ηλιόπουλου στο Π.Γ.Ν ΑΤΤΙΚΟΝ
Ομιλία του καθ. κ. Αριστείδη Ηλιόπουλου στο Π.Γ.Ν ΑΤΤΙΚΟΝ με θέμα: «Ανακάλυψη αντικαρκινικής δραστικότητας σε χημικές ενώσεις-παράγωγα της ενόνης» μετά από πρόσκληση της καθ. Ογκολογίας κ. Αμάντα Ψυρρή.
To PRETORIAN στα νέα του ΕΚΠA
Αναφορά στον καθηγητή κ. Ηλιόπουλο και την ομάδα PRETORIAN στο Hub του ΕΚΠΑ για την κατάθεση αιτήματος ευρεσιτεχνίας στο European Patent Office (EPO).
